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Young Blood Reverses Signs of Aging in Old Mice

Continued from page 1

By Emily Singer

Wednesday, January 27, 2010

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The regenerative power of young blood appears to be mediated by osteoblasts--bone-forming stem cells previously shown to play a role in regulating blood-forming stem cells. Researchers found that osteoblasts from old animals can make blood-forming stem cells from young mice act old. And conversely, surgically exposing old mice to young blood rejuvenates aged osteoblasts, restoring their capacity to properly regulate blood-forming stem cells.

Researchers haven't yet identified the mysterious molecule in blood that controls these aging effects. But insulin-like growth factor 1 (IGF-1), a hormone that has been shown to regulate longevity in a number of organisms, may play a key role. Researchers found that they could partially correct aging defects in osteoblasts by suppressing IGF-1. On the other hand, suppressing IGF-1 in muscle cells has the opposite effect, highlighting the complex role this molecule probably plays in aging.

It remains to be seen just what effect rejuvenating the circulatory system will have on the animals long-term. For example, scientists haven't assessed whether older mice surgically exposed to young blood are more resistant to infection than their normal aged counterparts. "But there are lots of reasons to link changes in [the circulatory system] with changes in the immune system," said Wagers. Older mice produce fewer lymphocytes, which respond to viruses and other pathogens. And they produce more myeloid cells, which tend to promote inflammatory conditions. "In a lot of tissues, you see an increase in inflammation that occurs with age," said Wagers.

The research also has important implications for regenerative medicine, such as stem cell transplants. "Most effort has focused on how to make [replacement] cells," says Linheng Li, a researcher at the Stowers Institute for Medical Research, in Kansas City, MO, who was not involved the study. "But we need to focus on making cells that function properly." Blood-forming stem cells, for example, are made in great quantities with age. But those cells don't work as well as younger ones. "It highlights the importance of the environment into which you transplant them," said Wagers. "If you take young healthy cells, and put them into an old environment, you might not get the full regenerative benefit of the cells."

Comments

  • Lifeblood
    It is interesting how many times the Hebrew Scriptures say, "the life is in the blood."  Do other ancient religious texts say similar things?
    Rate this comment: 12345

    dmm
    01/27/2010
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    • Re: Lifeblood
      By written accounts the Mayan's sacrifices were very bloody offerings to the gods.  Perhaps they sensed that blood had something to do with life--and if we have some 5th codec maybe we would see something mentioned.  But the ancients probably saw blood in the context of someone getting hacked.  Upon observation of that person turning pale and died after losing blood, they concluded that blood is the stuff of life.

      This idea delves into the Italian macabre movies of the 70's--they have got it right.  But give credit to the person who had the guts to propose this idea and carried out the experiment.
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      doanwon
      01/28/2010
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  • Pregnant women
    I wonder whether the fetus' blood affects a pregnant woman in this way, to some degree. Their circulatory systems are connected, though there must be some filtering to avoid immune interactions.
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    rkomatsu
    01/28/2010
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    • Re: Pregnant women
      That is interesting and explains the 'glow'.  But from my understanding there is no intermingling of the fetus and maternal blood.  The fetus umbillical cord is connected to the placenta where the exchange of nutrients and gas occur.  So the baby is isolated from the mother's blood.  Is it the chemicals responsible for reverse aging in the blood or in the blood cells?
      Rate this comment: 12345

      doanwon
      01/28/2010
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      • Re: Pregnant women
        Correct.  There is no mingling of fetal and maternal blood.  The placenta prevents mingling but lots of different plasma proteins do cross the placental barrier.
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        vanslix
        01/28/2010
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      • Re: Pregnant women
        Since the placenta is created and sustained by the mother's body, wouldn't this question still apply? At some level the child's blood must be linked with its mother's. Case in point is the transmission of Lyme Disease bacteria from mothers to fetuses in utero. Also, pregnant women are often noted for their increased beauty, as if some force were invigorating them and creating a deepened beauty.

        Of course, this might also be the result of an interaction between the apparently anaerobic metabolism of the fetus creating a negative ionic energy that creates a magnetic tension with the mother's positive ionic energies. (My take on Asian yin/yang theory.)
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        Rose of Shar...
        01/31/2010
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  • what's in young blood?
    I am wondering if the mystery substance in young blood that invigorated the older mice' signs of aging is not a chemical, but rather energy itself. From Asian traditional beliefs (ie yin/yang theory) one learns to see the body as a complex energy-generating mechanism. The more one moves, and the more intense the exercise/emotions, the greater one's ionic energy production and reserves. So, the older one gets, the less energy would be circulating or available, as one moves less, the movement/emotions decrease in intensity and one's systems produce/retain energy less efficiently.

    Thus, like caffeine on the American consciousness-- ionic energies might revitalize/reinvigorate tired, wounded, old systems...

    ............

    Related to this topic, I would add as a caution that the above ideas are derived from experience with Asian/New Age practices, and my experience suggests sickness caused by such practices. It may even be that practitioners have learned to use bacteria/fungus/viral elements to enhance such physiological energy effects (hence the awesome board-breaking abilities and other physiological feats of strength and prowess as well as development of psychic powers). And, one must also question-- if true, are such practices healthy, particularly when not regulated or authorized by our society? What of the consequences to public health?)

    The presence of an underlying systemic fungal and/or bacterial connection could also explain Asian concepts like the mysterious "Triple Burner organ" (which might be related to the nervous-endocrine-immune system interconnection, but made far more intense, probably related to triggering of the anaerobic/stress system)and chi meridians that that appear to correlate loosely to nerve centers identified by Western scientific understanding. Interestingly certain bacteria (like Lyme Disease) and fungi require zinc for growth, while zinc is also used in electrical systems as a fuse. So an overgrowth of these pathogens would cause normal body channels to become a kind of electrical channel.

    So, in studying the topic of how to research and apply the benefits of "young blood", please recognize that this might not be such a new topic, nor one without grave ethical responsibilities. It is no good to anyone to regain one's youth, but lose the essence of our being-- the normal function of our organs/systems and the development of the body into what amounts to be a giant magnet capable of exerting positive or negative energy vibes capable of attracting or repelling the energies of others without their expressed consent or even recognition.

    God bless,
    Rate this comment: 12345

    Rose of Shar...
    01/31/2010
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  • Telomeres?
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    Phineas
    02/02/2010
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  • stem cells in the blood
    I wonder if the stem cells in the younger animal were traveling to the older animal, and account for the blood-cell ratios.
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    aerospaceguy
    02/03/2010
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